Title : The role of glycerol-3-phosphate dehydrogenase 1 in the progression of fatty liver after acute ethanol administration in mice.

Pub. Date : 2014 Feb 21

PMID : 24472537






4 Functional Relationships(s)
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1 Although glycerol-3-phosphate (Gro3P), formed by glycerol kinase (GYK) or glycerol-3-phosphate dehydrogenase 1 (GPD1), is also required for TG synthesis, the roles of GYK and GPD1 have been the subject of some debate. Triglycerides glycerol-3-phosphate dehydrogenase 1 (soluble) Mus musculus
2 Although glycerol-3-phosphate (Gro3P), formed by glycerol kinase (GYK) or glycerol-3-phosphate dehydrogenase 1 (GPD1), is also required for TG synthesis, the roles of GYK and GPD1 have been the subject of some debate. Triglycerides glycerol-3-phosphate dehydrogenase 1 (soluble) Mus musculus
3 In conclusion, GPD1 and glycolytic gene expression is up-regulated by ethanol, and GPD1-mediated incorporation of glucose into TG glycerol moieties together with increased lipogenesis, is suggested to play an important role in ethanol-induced hepatic TG accumulation. Triglycerides glycerol-3-phosphate dehydrogenase 1 (soluble) Mus musculus
4 In conclusion, GPD1 and glycolytic gene expression is up-regulated by ethanol, and GPD1-mediated incorporation of glucose into TG glycerol moieties together with increased lipogenesis, is suggested to play an important role in ethanol-induced hepatic TG accumulation. Triglycerides glycerol-3-phosphate dehydrogenase 1 (soluble) Mus musculus