Title : Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.

Pub. Date : 2014 Apr

PMID : 24472059






2 Functional Relationships(s)
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1 We showed that adenosine 5"-[gamma-thio]triphosphate tetralithium salt (ATPgammaS) and 2",3"-O-(4-benzoylbenzoyl) adenosine 5"-triphosphate (BzATP), two stable analogs of ATP, are able to potentiate the release of IL-1beta from human monocyte-derived macrophages induced by low concentration of lipopolysaccharide (LPS). BzATP interleukin 1 beta Homo sapiens
2 NLRP3 and IL-1beta mRNA expression were induced from LPS-primed macrophages, but also after 5-h treatment of BzATP as analysed by reverse transcription quantitative polymerase chain reaction. BzATP interleukin 1 beta Homo sapiens