Title : c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA.

Pub. Date : 2014 Mar 21

PMID : 24464582






2 Functional Relationships(s)
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1 In this study, we show that Pu-27 induces profound DNA damage, resulting in striking chromosomal abnormalities in the form of chromatid or chromosomal breaks, radial formation, and telomeric DNA loss, which induces gamma-H2AX in U937 cells. Plutonium H2A.X variant histone Homo sapiens
2 Telomere dysfunction-induced foci assay revealed co-association of TRF1with gamma-H2AX in ATM deficient cells, which are differentially sensitive to Pu-27 than ATM proficient cells. Plutonium H2A.X variant histone Homo sapiens