Title : The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex.

Pub. Date : 2014 Jan 23

PMID : 24457959






3 Functional Relationships(s)
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1 The dissociation constant of the heterocomplex is K(d)=0.3 muM; however the binding affinity strongly decreases when the active site of GSTP1-1 is occupied by the substrate GSH (K(d)>=2.6 muM) or is inactivated by oxidation (Kd=1.7 muM). Glutathione latexin Homo sapiens
2 The dissociation constant of the heterocomplex is K(d)=0.3 muM; however the binding affinity strongly decreases when the active site of GSTP1-1 is occupied by the substrate GSH (K(d)>=2.6 muM) or is inactivated by oxidation (Kd=1.7 muM). Glutathione latexin Homo sapiens
3 The dissociation constant of the heterocomplex is K(d)=0.3 muM; however the binding affinity strongly decreases when the active site of GSTP1-1 is occupied by the substrate GSH (K(d)>=2.6 muM) or is inactivated by oxidation (Kd=1.7 muM). Glutathione latexin Homo sapiens