Title : Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1.

Pub. Date : 2014 Apr

PMID : 24448832






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In agreement with previous data that demonstrated extrusion of (glucosyl)ceramides by ABCB1 (Lee et al. Glucosylceramides ATP binding cassette subfamily B member 1 Canis lupus familiaris
2 In conclusion, nickel induces a ROS-ceramide pathway to cause apoptotic cell death as well as activate adaptive survival responses, including upregulation of ABCB1, which improves cell survival by extruding proapoptotic (glucosyl)ceramides. Glucosylceramides ATP binding cassette subfamily B member 1 Canis lupus familiaris