Pub. Date : 2014 Apr
PMID : 24444314
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we elucidated the anti-hypertrophic action of metformin, specifically, the role of the AMPK/eNOS/p53 pathway. | Metformin | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 2 | Metformin attenuated AngII-induced activation (cleavage) of caspase 3, Bcl-2 down-regulation and p53 up-regulation. | Metformin | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 3 | Thus, this study demonstrates that the anti-hypertrophic effects of metformin are associated with AMPK-induced AT1R down-regulation and prevention of mitochondrial dysfunction through the SIRT1/eNOS/p53 pathway. | Metformin | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |