Title : Stratified control of IGF-I expression by hypoxia and stress hormones in osteoblasts.

Pub. Date : 2014 Apr 10

PMID : 24440782






4 Functional Relationships(s)
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1 Here we show that hypoxia and the stress hormones PGE2 and glucocorticoid interact in complex ways in osteoblasts, converging on insulin like growth factor I (IGF-I) expression. Dinoprostone insulin like growth factor 1 Homo sapiens
2 Here we show that hypoxia and the stress hormones PGE2 and glucocorticoid interact in complex ways in osteoblasts, converging on insulin like growth factor I (IGF-I) expression. Dinoprostone insulin like growth factor 1 Homo sapiens
3 Notably, hypoxia increased expression of the acute phase response transcription factor C/EBPdelta which can induce IGF-I in response to PGE2, but conversely prevented the stimulatory effect of PGE2 on IGF-I mRNA. Dinoprostone insulin like growth factor 1 Homo sapiens
4 Notably, hypoxia increased expression of the acute phase response transcription factor C/EBPdelta which can induce IGF-I in response to PGE2, but conversely prevented the stimulatory effect of PGE2 on IGF-I mRNA. Dinoprostone insulin like growth factor 1 Homo sapiens