Pub. Date : 2014 Apr
PMID : 24437490
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By inhibiting androgen-dependent IGF-IR up-regulation, metformin reduced IGF-I-mediated proliferation of LNCaP cells. | Metformin | insulin like growth factor 1 | Homo sapiens |
| 2 | These results indicate that, in prostate cancer cells, metformin inhibits IGF-I-mediated biological effects by disrupting membrane-initiated AR action responsible for IGF-IR up-regulation and suggest that metformin could represent a useful adjunct to the classical antiandrogen therapy. | Metformin | insulin like growth factor 1 | Homo sapiens |
| 3 | These results indicate that, in prostate cancer cells, metformin inhibits IGF-I-mediated biological effects by disrupting membrane-initiated AR action responsible for IGF-IR up-regulation and suggest that metformin could represent a useful adjunct to the classical antiandrogen therapy. | Metformin | insulin like growth factor 1 | Homo sapiens |