Title : YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma.

Pub. Date : 2014 Jan 13

PMID : 24418169






1 Functional Relationships(s)
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1 Combination of sorafenib and YC-1 significantly inhibited the expression of p-STAT3 (Y705) (S727), p-ERK1/2, cyclin D1 and survivin and SHP-1 activity compared with sorafenib or YC-1 used alone in all tested HCC cell lines. Sorafenib nuclear receptor subfamily 0 group B member 2 Homo sapiens