Title : Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract.

Pub. Date : 2014 Feb 27

PMID : 24412547






2 Functional Relationships(s)
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1 ETHNOPHARMACOLOGICAL RELEVANCE: Aquaporin-3 (AQP3) is expressed in mucosal epithelial cells in the colon and is important for regulating fecal water content. Water aquaporin 3 (Gill blood group) Homo sapiens
2 CONCLUSIONS: Sennoside A may decrease AQP3 expression in the colon to inhibit water transport from the luminal to the vascular side, leading to a laxative effect. Water aquaporin 3 (Gill blood group) Homo sapiens