Title : The conformational changes of alpha 2-macroglobulin induced by methylamine or trypsin. Characterization by extrinsic and intrinsic spectroscopic probes.

Pub. Date : 1987 Apr 1

PMID : 2440424






1 Functional Relationships(s)
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Protein Name
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1 Reaction of trypsin with thiol-labelled methylamine-treated bovine alpha 2M, which retains a near-native conformation and inhibitory activity, indicated that the major conformational change accompanying the binding of proteinases involves transfer of the thioester-bond region to a more polar environment without increasing the exposure of this region at the surface of the protein. Sulfhydryl Compounds alpha-2-macroglobulin Bos taurus