Pub. Date : 2014 Apr 17
PMID : 24394665
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34(+) cells. | Bortezomib | lymphoid enhancer binding factor 1 | Homo sapiens |
| 2 | The proteasome inhibitor bortezomib reversed the defective G-CSF-triggered granulocytic differentiation of CD34(+) cells from CN patients in vitro, an effect that was accompanied by restoration of LEF-1 protein levels and LEF-1 messenger RNA autoregulation. | Bortezomib | lymphoid enhancer binding factor 1 | Homo sapiens |
| 3 | The proteasome inhibitor bortezomib reversed the defective G-CSF-triggered granulocytic differentiation of CD34(+) cells from CN patients in vitro, an effect that was accompanied by restoration of LEF-1 protein levels and LEF-1 messenger RNA autoregulation. | Bortezomib | lymphoid enhancer binding factor 1 | Homo sapiens |