Title : Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells.

Pub. Date : 2014 Jun

PMID : 24394624






2 Functional Relationships(s)
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1 We also found perifosine, a novel AKT inhibitor, down-regulated GLI1 protein by dephosphorylation of AKT and GSK3beta dose-dependently and that pre-treatment with PD98059, a MEK/ERK pathway inhibitor, enhanced this down-regulation by 20%-30%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one AKT serine/threonine kinase 1 Homo sapiens
2 We also found perifosine, a novel AKT inhibitor, down-regulated GLI1 protein by dephosphorylation of AKT and GSK3beta dose-dependently and that pre-treatment with PD98059, a MEK/ERK pathway inhibitor, enhanced this down-regulation by 20%-30%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one AKT serine/threonine kinase 1 Homo sapiens