Title : Cells with impaired mitochondrial H2O2 sensing generate less •OH radicals and live longer.

Pub. Date : 2014 Oct 1

PMID : 24382195






1 Functional Relationships(s)
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1 In contrast, young ccp1(W191F) cells accumulate little H2O2, possess depressed Sod2 activity, enabling their O2( -) level to spike and deactivate aconitase, which, ultimately, leads to greater mitochondrial oxidative damage, early GSH depletion, and a shorter lifespan than wild-type cells. Hydrogen Peroxide cytochrome-c peroxidase Saccharomyces cerevisiae S288C