Title : Effects of aldehyde dehydrogenase inhibitors on hexobarbital sensitivity and neuroamine metabolism in rat brain.

Pub. Date : 1987 Apr 21

PMID : 2438009






3 Functional Relationships(s)
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1 Several authors have found that the aldehyde dehydrogenase (ALDH) inhibitor, disulfiram, prolongs hexobarbital-induced anaesthesia. Disulfiram aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
2 Several authors have found that the aldehyde dehydrogenase (ALDH) inhibitor, disulfiram, prolongs hexobarbital-induced anaesthesia. Disulfiram aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
3 In the present study, disulfiram (300 mg/kg) was found to cause a 4-fold prolongation of hexobarbital-induced anaesthesia, while coprine (another potent ALDH-inhibitor) had no effect. Disulfiram aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus