Title : Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation.

Pub. Date : 2014 May

PMID : 24375173






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Mechanistically, the nuclear transportation of p65 and p53 was reduced by UA administration prior to UVR exposure while the levels of p65 and p53 nuclear transportation in SM cells were sustained at a substantially higher level. ursolic acid tumor protein p53 Homo sapiens
2 These results were consistent with reduced proliferation observed in the clonogenic assay, indicating that UA treatment enhanced the phototoxicity of UVR, by modulating the activation of p53 and NF-kappaB and initiating a mitogenic response to optical radiation that triggered mitochondria-dependent apoptosis, particularly in skin melanoma cells. ursolic acid tumor protein p53 Homo sapiens