Pub. Date : 2014 Feb 15
PMID : 24370341
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells. | Cisplatin | microRNA 205 | Homo sapiens |
| 2 | In the present study, we show that miR-205 replacement in castration-resistant mesenchymal prostate cancer cells caused an enhancement of cisplatin cytotoxic activity in vitro and in vivo, as a consequence of autophagy impairment. | Cisplatin | microRNA 205 | Homo sapiens |
| 3 | These findings suggest that miR-205-mediated impairment of the autophagic pathway may interfere with the detoxifying capabilities of prostate cancer cells in their attempt to cope with cisplatin-induced detrimental effects. | Cisplatin | microRNA 205 | Homo sapiens |