Title : HDAC inhibitors restore the capacity of aged mice to respond to haloperidol through modulation of histone acetylation.

Pub. Date : 2014 May

PMID : 24366052






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In addition, HAL-induced c-Fos expression in the nucleus accumbens shell and prefrontal cortex was significantly lower in aged mice as compared with young mice. Haloperidol FBJ osteosarcoma oncogene Mus musculus
2 Also, VPA and MS-275 pretreatment restored HAL-induced increases in c-Fos expression in the nucleus accumbens shell and prefrontal cortex of aged mice to levels comparable with those observed in young mice. Haloperidol FBJ osteosarcoma oncogene Mus musculus
3 Lastly, but most importantly, increases in c-Fos expression and HAL efficacy in the CAR test of the HAL+VPA and HAL+MS-275 groups were correlated with elevated histone acetylation at the c-fos promoter region in aged mice. Haloperidol FBJ osteosarcoma oncogene Mus musculus
4 Lastly, but most importantly, increases in c-Fos expression and HAL efficacy in the CAR test of the HAL+VPA and HAL+MS-275 groups were correlated with elevated histone acetylation at the c-fos promoter region in aged mice. Haloperidol FBJ osteosarcoma oncogene Mus musculus
5 Lastly, but most importantly, increases in c-Fos expression and HAL efficacy in the CAR test of the HAL+VPA and HAL+MS-275 groups were correlated with elevated histone acetylation at the c-fos promoter region in aged mice. Haloperidol FBJ osteosarcoma oncogene Mus musculus
6 Lastly, but most importantly, increases in c-Fos expression and HAL efficacy in the CAR test of the HAL+VPA and HAL+MS-275 groups were correlated with elevated histone acetylation at the c-fos promoter region in aged mice. Haloperidol FBJ osteosarcoma oncogene Mus musculus