Title : Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation.

Pub. Date : 2014 Feb 15

PMID : 24363449






2 Functional Relationships(s)
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1 Finally, although the combination of MEK1/2 inhibitors with mTOR inhibitors is an attractive rational drug combination, SW620:8055R cells were actually cross-resistant to the MEK1/2 inhibitor selumetinib (AZD6244). AZD 6244 mitogen-activated protein kinase kinase 1 Homo sapiens
2 Finally, although the combination of MEK1/2 inhibitors with mTOR inhibitors is an attractive rational drug combination, SW620:8055R cells were actually cross-resistant to the MEK1/2 inhibitor selumetinib (AZD6244). AZD 6244 mitogen-activated protein kinase kinase 1 Homo sapiens