Pub. Date : 2014 Mar 5
PMID : 24361490
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 2 | Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 3 | Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 4 | Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 5 | Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 6 | Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 7 | Taken together, these data demonstrate that BaP induces differentiation of placental trophoblastic BeWo cells in an AhR- and p53-dependent manner. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |