Pub. Date : 2014 Aug
PMID : 24357007
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells. | Fenretinide | stearoyl-CoA desaturase | Homo sapiens |
| 2 | We examined whether fenretinide, (N-(4-hydroxyphenyl)retinamide, 4HPR), which induces apoptosis in cancer cells and recently shown to improve insulin sensitivity, can modulate the expression of SCD. | Fenretinide | stearoyl-CoA desaturase | Homo sapiens |
| 3 | We examined whether fenretinide, (N-(4-hydroxyphenyl)retinamide, 4HPR), which induces apoptosis in cancer cells and recently shown to improve insulin sensitivity, can modulate the expression of SCD. | Fenretinide | stearoyl-CoA desaturase | Homo sapiens |
| 4 | We examined whether fenretinide, (N-(4-hydroxyphenyl)retinamide, 4HPR), which induces apoptosis in cancer cells and recently shown to improve insulin sensitivity, can modulate the expression of SCD. | Fenretinide | stearoyl-CoA desaturase | Homo sapiens |
| 5 | We observed that fenretinide decreased SCD protein and enzymatic activity in the ARPE-19 human retinal pigment epithelial cell line. | Fenretinide | stearoyl-CoA desaturase | Homo sapiens |
| 6 | In addition, PYR41, an inhibitor of ubiquitin activating enzyme E1, blocked the fenretinide-mediated decrease in SCD. | Fenretinide | stearoyl-CoA desaturase | Homo sapiens |
| 7 | Immunoprecipitation analysis using anti-ubiquitin and anti-SCD antibodies and the blocking of SCD loss by PYR41 inhibition of ubiquitination further corroborate that fenretinide mediates the degradation of SCD in human RPE cells via the ubiquitin-proteasome dependent pathway. | Fenretinide | stearoyl-CoA desaturase | Homo sapiens |
| 8 | Immunoprecipitation analysis using anti-ubiquitin and anti-SCD antibodies and the blocking of SCD loss by PYR41 inhibition of ubiquitination further corroborate that fenretinide mediates the degradation of SCD in human RPE cells via the ubiquitin-proteasome dependent pathway. | Fenretinide | stearoyl-CoA desaturase | Homo sapiens |
| 9 | Therefore, the effect of fenretinide on SCD should be considered in its potential therapeutic role against cancer, type-2 diabetes, and retinal diseases. | Fenretinide | stearoyl-CoA desaturase | Homo sapiens |