Title : Altered mechano-chemical environment in hip articular cartilage: effect of obesity.

Pub. Date : 2014 Oct

PMID : 24352367






3 Functional Relationships(s)
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1 A new computational model, based on the mechano-electrochemical mixture theory, was developed to describe competitive binding kinetics of IGF-1 with IGFBP and CSR, and associated glycosaminoglycan (GAG) biosynthesis. Glycosaminoglycans insulin like growth factor 1 Homo sapiens
2 A new computational model, based on the mechano-electrochemical mixture theory, was developed to describe competitive binding kinetics of IGF-1 with IGFBP and CSR, and associated glycosaminoglycan (GAG) biosynthesis. Glycosaminoglycans insulin like growth factor 1 Homo sapiens
3 Results indicated that the lower ratio of IGF-1 to IGFBP found in obese population reduces cartilage GAG concentration up to 18 % when compared to normal population. Glycosaminoglycans insulin like growth factor 1 Homo sapiens