Title : ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.

Pub. Date : 2014 Mar 1

PMID : 24351425






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Similar to K-RAS-mutated cells, increased K-RAS activity in HNSCC cells overexpressing K-RASwt was associated with the stimulated production of the EGFR ligand amphiregulin and resistance to EGFR tyrosine kinase (EGFR-TK) inhibitors such as erlotinib. Erlotinib Hydrochloride amphiregulin Homo sapiens