Pub. Date : 2013
PMID : 24335179
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine suppresses TPA-induced fibronectin expression through the inhibition of VEGF secretion in breast cancer cells. | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |
| 2 | Here, we investigated the effect of BBR on TPA-induced VEGF and fibronectin (FN) as well as VEGF-induced FN in breast cancer cells. | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |
| 3 | RESULTS: Our results showed that TPA, a tumor promoter, significantly increased the level of VEGF and FN expression in both MCF7 and T47D breast cancer cells. | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |
| 4 | On the other hand, TPA-induced VEGF and FN expression was suppressed by LY294002, a PI-3K inhibitor. | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |
| 5 | We also found that TPA-induced VEGF and FN expression was decreased by BBR treatment. | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |
| 6 | CONCLUSION: Taken together, we suggest that BBR may suppress TPA-induced VEGF and FN as well as VEGF-induced FN through the inhibition of the PI-3K/AKT pathway in breast cancer cells. | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |