Pub. Date : 2013 Sep
PMID : 24332050
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effect of doxorubicin on TRAIL resistance and TRAIL receptor expression in lymphoma cell line SNK-6 cells]. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 2 | OBJECTIVE: To investigate the effect of doxorubicin on TRAIL resistance and TRAIL receptor expression in lymphoma cell line SNK-6 cells. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 3 | METHODS: SNK-6 cells treated with doxorubicin at different concentrations alone or in combination with tumor necrosis factor related apoptosis inducing ligand (TRAIL). | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 4 | RESULTS: MTT assay showed that treatment with 100 and 1000 ng/ml doxorubicin for 24 h, the survival rates of SNK-6 cells were (80.9 +- 7.2)% and (53.7 +- 2.8)%, significantly higher than that by treatment combined with 500 ng/ml TRAIL (64.9 +- 1.1)% and (34.0 +- 3.9)%, respectively (P < 0.05). | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 5 | Flow cytometry showed that after treatment with 100 and 1000 ng/ml doxorubicin for 48 h, the survival rates of SNK-6 cells were (69.9 +- 6.1)% and (31.1 +- 1.9)%, while treated in combination with 500 ng/ml TRAIL, the cell survival rates were (37.5 +- 6.4)% and (15.0 +- 1.8)%, respectively. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 6 | The expressions of TRAIL receptors and decoy receptors were increased when SNK-6 cells were treated with 100 ng/ml doxorubicin for 24 hours. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 7 | CONCLUSIONS: Doxorubicin can overcome to a certain extent the TRAIL resistance of SNK-6 cells and induce upregulation of TRAIL death receptors and decoy receptors on the surface of SNK-6 cells. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 8 | CONCLUSIONS: Doxorubicin can overcome to a certain extent the TRAIL resistance of SNK-6 cells and induce upregulation of TRAIL death receptors and decoy receptors on the surface of SNK-6 cells. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |