Title : Role of oxygen in the regulation of Leydig tumor derived MA-10 cell steroid production: the effect of cobalt chloride.

Pub. Date : 2014 Apr

PMID : 24328340






1 Functional Relationships(s)
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1 The decrease in progesterone production could be attributed to three different mechanisms, (1) an increase in production of reactive oxygen species (ROS), (2) an increase in HIF-1alpha activity, and (3) ultimately a decrease in the level of cytochrome P450 side chain cleavage (CYT P450scc). Progesterone cytochrome P450, family 11, subfamily a, polypeptide 1 Mus musculus