Pub. Date : 2014 Jan 21
PMID : 24325674
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acrolein modification impairs key functional features of rat apolipoprotein E: identification of modified sites by mass spectrometry. | Acrolein | apolipoprotein E | Rattus norvegicus |
| 2 | The objective of this study is to examine the effect of acrolein modification on the structure and function of rat apoE and to determine the sites and nature of modification by mass spectrometry. | Acrolein | apolipoprotein E | Rattus norvegicus |
| 3 | Treatment of recombinant rat apoE with a 10-fold molar excess of acrolein resulted in (i) a significant decrease in lipid-binding and cholesterol efflux abilities, (ii) impairment in the LDLr- and heparin-binding capabilities, and (iii) significant alterations in the overall stability of the protein. | Acrolein | apolipoprotein E | Rattus norvegicus |
| 4 | Overall, disruption of the structural and functional integrity of apoE by oxidative modification of essential lysine residues by acrolein is expected to affect its role in maintaining plasma cholesterol homeostasis and lead to dysregulation in lipid metabolism. | Acrolein | apolipoprotein E | Rattus norvegicus |