Title : Characterization of the role of a highly conserved sequence in ATP binding cassette transporter G (ABCG) family in ABCG1 stability, oligomerization, and trafficking.

Pub. Date : 2013 Dec 31

PMID : 24320932






3 Functional Relationships(s)
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1 A more detailed mutagenesis study revealed that mutation of Asn316 or Phe 320 to Ala significantly reduced cellular cholesterol and 7-ketocholesterol efflux conferred by ABCG1, whereas replacement of Pro317 or Asp319 with Ala had no detectable effect. 7-ketocholesterol ATP binding cassette subfamily G member 1 Homo sapiens
2 However, the efflux of cholesterol and 7-ketocholesterol was reduced in cells expressing ABCG1 mutant N316D, N316Q, or F320I compared with wild type ABCG1. 7-ketocholesterol ATP binding cassette subfamily G member 1 Homo sapiens
3 However, the efflux of cholesterol and 7-ketocholesterol was reduced in cells expressing ABCG1 mutant N316D, N316Q, or F320I compared with wild type ABCG1. 7-ketocholesterol ATP binding cassette subfamily G member 1 Homo sapiens