Title : Antigenic alterations of carcinoembryonic antigen involved in the secretion from various human tumor cell lines.

Pub. Date : 1986 Oct

PMID : 2430922






3 Functional Relationships(s)
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1 On the other hand, with each of 4 monoclonal antibodies recognizing the carbohydrate epitopes, the reactivities of CEAs were found to be highly variable from one cell line to another, and a marked difference was detected between the reactivities of m-CEA and of c-CEA in every cell line. Carbohydrates CEA cell adhesion molecule 3 Homo sapiens
2 On the other hand, with each of 4 monoclonal antibodies recognizing the carbohydrate epitopes, the reactivities of CEAs were found to be highly variable from one cell line to another, and a marked difference was detected between the reactivities of m-CEA and of c-CEA in every cell line. Carbohydrates CEA cell adhesion molecule 3 Homo sapiens
3 These results suggest that distinct structural changes in the carbohydrate moiety may occur during the releasing process of CEA from cells, and that, in some cases, some epitopes may be masked by attachment of sialic acid residues. Carbohydrates CEA cell adhesion molecule 3 Homo sapiens