Title : Regioselective dehydrogenation of 3-keto-steroids to form conjugated enones using o-iodoxybenzoic acid and trifluoroacetic acid catalysis.

Pub. Date : 2014 Feb

PMID : 24309193






1 Functional Relationships(s)
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1 Mild and regioselective conversion of 3-keto-5alpha- and 3-keto-5beta-steroids (trans A/B- and cis A/B-ring juncture, respectively) to the corresponding enones (Delta(1)- and Delta(4)-3-ketones) by treatment with o-iodoxybenzoic acid (IBX) catalyzed by trifluoroacetic acid (TFA) in DMSO, is described. enones delta like non-canonical Notch ligand 1 Homo sapiens