Pub. Date : 2013 Jul
PMID : 24303204
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Original Nerve Growth Factor Mimetic Dipeptide GK-2 Restores Impaired Cognitive Functions in Rat Models of Alzheimer"s Disease. | Dipeptides | glycerol kinase 2 | Rattus norvegicus |
| 2 | Dipeptide mimetic of the nerve growth factor (NGF) loop 4, hexamethylenediamide bis-(N-monosuccinyl- glutamyl-lysine) (GK-2), was synthesized at the V.V. | Dipeptides | glycerol kinase 2 | Rattus norvegicus |
| 3 | Dipeptide GK-2 at a dose of 1 mg/kg is found to decrease the habituation deficit induced by the septo-hippocampal pathway transsection and, at a dose of 0.5 mg/kg, to significantly prevent spatial memory impairment in Morris water maze induced by intracerebral injection of streptozotocin. | Dipeptides | glycerol kinase 2 | Rattus norvegicus |
| 4 | Thus, GK-2, an original dipeptide mimetic of NGF, acts on models of the Alzheimer"s disease upon systemic administration. | Dipeptides | glycerol kinase 2 | Rattus norvegicus |