Title : Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids.

Pub. Date : 2014 Jan 15

PMID : 24302004






1 Functional Relationships(s)
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1 Exposure of HepG2 cells to excess amino acids reduced AMPK phosphorylation, upregulated Notch1 expression, and impaired the insulin-stimulated phosphorylation of Akt Ser(473) and insulin receptor substrate-1 (IRS-1) Tyr(612). Tyrosine AKT serine/threonine kinase 1 Homo sapiens