Title : Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity.

Pub. Date : 2013 Oct 12

PMID : 24283803






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 CK2 negative regulation of the protein levels of tumor suppressor p53 and activation of the STAT3 anti-apoptotic pathway might antagonize apoptosis and could be involved in acute myeloid leukemia cell resistance to daunorubicin. Daunorubicin tumor protein p53 Homo sapiens