Title : Role and mechanism of microglial activation in iron-induced selective and progressive dopaminergic neurodegeneration.

Pub. Date : 2014 Jun

PMID : 24277523

1 Functional Relationships(s)
Compound Name
Protein Name
1 NOX2 inhibitor diphenylene iodonium protects against iron-elicited dopaminergic neurotoxicity through decreasing microglial O2 - generation, and NOX2-/- mice are resistant to the neurotoxicity by reducing microglial O2 - production, indicating that iron-elicited dopaminergic neurotoxicity is dependent of NOX2, a O2 --generating enzyme. Superoxides cytochrome b-245, beta polypeptide Mus musculus