Title : Hypoxia and hypoxia mimetic cooperate to counteract tumor cell resistance to glucose starvation preferentially in tumor cells with mutant p53.

Pub. Date : 2014 Jan 3

PMID : 24275138






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Others subsequently indicated that mutant p53 tumor cells undergo p53 degradation and cell death under aerobic glucose-free conditions. Glucose tumor protein p53 Homo sapiens
2 Others subsequently indicated that mutant p53 tumor cells undergo p53 degradation and cell death under aerobic glucose-free conditions. Glucose tumor protein p53 Homo sapiens
3 p53 Silencing decreased survival of glucose-starved C8161 melanoma with pyruvate supplementation under hypoxia (<=1% oxygen), but increased resistance to glycolytic inhibitors oxamate and 2-deoxyglucose in 5mM glucose, preferentially under normoxia. Glucose tumor protein p53 Homo sapiens
4 p53 Silencing decreased survival of glucose-starved C8161 melanoma with pyruvate supplementation under hypoxia (<=1% oxygen), but increased resistance to glycolytic inhibitors oxamate and 2-deoxyglucose in 5mM glucose, preferentially under normoxia. Glucose tumor protein p53 Homo sapiens