Title : Construction and application of double-transfected cells expressing the human transporter P-glycoprotein and cytochrome P450 3A4.

Pub. Date : 2013 Oct

PMID : 24273886






2 Functional Relationships(s)
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1 The expression of CYP3A4 in the double-transfected cell line was determined by Western blot and its activity was detected by the metabolism assays of three substrates of CYP3A4, which were 7-benzyloxy-4-trifluoro-methylcoumarin (BFC), testosterone and midazolam. Midazolam cytochrome P450 3A12 Canis lupus familiaris
2 The expression of CYP3A4 in the double-transfected cell line was determined by Western blot and its activity was detected by the metabolism assays of three substrates of CYP3A4, which were 7-benzyloxy-4-trifluoro-methylcoumarin (BFC), testosterone and midazolam. Midazolam cytochrome P450 3A12 Canis lupus familiaris