Pub. Date : 2013
PMID : 24260284
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The Cytochrome P450 2B6 (CYP2B6) enzyme makes a small contribution to hepatic nicotine metabolism relative to CYP2A6, but CYP2B6 is the primary enzyme responsible for metabolism of the smoking cessation drug bupropion. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | The Cytochrome P450 2B6 (CYP2B6) enzyme makes a small contribution to hepatic nicotine metabolism relative to CYP2A6, but CYP2B6 is the primary enzyme responsible for metabolism of the smoking cessation drug bupropion. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | Using CYP2A6 genotype as a covariate, we find that a non-coding polymorphism in CYP2B6 previously associated with smoking cessation (rs8109525) is also significantly associated with nicotine metabolism. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |