Pub. Date : 2014 Mar
PMID : 24256608
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate methyltransferase activity. | Creatine | guanidinoacetate N-methyltransferase | Rattus norvegicus |
| 2 | One such methyltransferase is guanidinoacetate methyltransferase (GAMT) that catalyzes the last step of creatine synthesis. | Creatine | guanidinoacetate N-methyltransferase | Rattus norvegicus |
| 3 | One such methyltransferase is guanidinoacetate methyltransferase (GAMT) that catalyzes the last step of creatine synthesis. | Creatine | guanidinoacetate N-methyltransferase | Rattus norvegicus |
| 4 | Further, in vitro experiments with cell-free system and hepatic cells revealed it is indeed elevated SAH and lower SAM:SAH ratio that directly impairs GAMT activity and significantly reduces creatine synthesis. | Creatine | guanidinoacetate N-methyltransferase | Rattus norvegicus |
| 5 | EtOH intake also slightly decreases the hepatocellular uptake of the creatine precursor, guanidinoacetate (GAA), and the GAMT enzyme expression that could additionally contribute to reduced liver creatine synthesis. | Creatine | guanidinoacetate N-methyltransferase | Rattus norvegicus |