Title : The role of melatonin in pancreatic protection: could melatonin be used in the treatment of acute pancreatitis?

Pub. Date : 2014

PMID : 24251674






1 Functional Relationships(s)
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1 In the pancreas melatonin and L-tryptophan activate complex mechanisms which involve direct scavenging of the radical oxygen and nitrogen species, activation of antioxidant enzymes (catalase, superoxide dysmutase, glutation peroxidase), reduction of pro-inflammatory cytokines and prostaglandins, activation of heat shock protein, and a decrease of necrosis and increase of regeneration in the pancreas. Melatonin catalase Homo sapiens