Title : Regulation of interleukin 1 production by mouse peritoneal macrophages. Effects of arachidonic acid metabolites, cyclic nucleotides, and interferons.

Pub. Date : 1986 Jul 5

PMID : 2424900






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 IL 1 production was inhibited by PGE2, the adenosine 3":5"-monophosphate analog dibutyryl cAMP, the cAMP agonist isoproterenol, and the phosphodiesterase inhibitor isobutylmethylxanthine. Dinoprostone interleukin 1 complex Mus musculus
2 Production of both the intracellular and extracellular forms of IL 1 was blocked by PGE2 and cAMP. Dinoprostone interleukin 1 complex Mus musculus
3 Suppression of LPS-induced IL 1 production by PGE2 was prevented by leukocyte alpha-interferon. Dinoprostone interleukin 1 complex Mus musculus
4 Thus, net IL 1 production by macrophages may be regulated by a balance between the effects of PGE2, cAMP, alpha-interferon, and gamma-interferon, but not LTB4. Dinoprostone interleukin 1 complex Mus musculus