Title : Epigallocatechin-3-gallate ameliorates both obesity and autoinflammatory arthritis aggravated by obesity by altering the balance among CD4+ T-cell subsets.

Pub. Date : 2014 Jan-Feb

PMID : 24239847






3 Functional Relationships(s)
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1 EGCG also induced a higher Treg/Th17 cell ratio in CD4(+) T-cell differentiation by decreasing the ratio of STAT3/STAT5 expression in DIO mice. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
2 Thus, EGCG has an anti-inflammatory effect by suppressing STAT3 proteins and Th17-cell differentiation. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
3 EGCG thus shows promise for treating autoimmune conditions related to STAT3 or Th17 cells, such as metabolic syndrome, inflammatory arthritis, and some neoplastic diseases. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus