Title : Chemical and enzymatic approaches to the synthesis of optically pure ethyl (R)-4-cyano-3-hydroxybutanoate.

Pub. Date : 2014 Jan

PMID : 24232833






2 Functional Relationships(s)
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1 Ethyl (R)-4-cyano-3-hydroxybutanoate (HN) is an important chiral synthon for side chain of the cholesterol-lowering drug atorvastatin (Lipitor), which is the hydroxymethylglutaryl CoA reductase inhibitor. Atorvastatin 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens
2 Ethyl (R)-4-cyano-3-hydroxybutanoate (HN) is an important chiral synthon for side chain of the cholesterol-lowering drug atorvastatin (Lipitor), which is the hydroxymethylglutaryl CoA reductase inhibitor. Atorvastatin 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens