Title : [Effect of the methylation enzyme inhibitors of 5-aza-2-deoxycytidine on the TGF-beta/smad signal transduction pathway in human keloid fibroblasts].

Pub. Date : 2013 Jul

PMID : 24228511






3 Functional Relationships(s)
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1 [Effect of the methylation enzyme inhibitors of 5-aza-2-deoxycytidine on the TGF-beta/smad signal transduction pathway in human keloid fibroblasts]. Decitabine transforming growth factor beta 1 Homo sapiens
2 OBJECTIVE: To investigate the effect of 5-aza-2-deoxycytidine on the TGF-beta/smad signal transduction pathway in human keloid fibroblasts (KFSs). Decitabine transforming growth factor beta 1 Homo sapiens
3 CONCLUSIONS: 5-aza-2-deoxycytidine, methylase inhibitors, inhibits cell proliferation and promotes apoptosis of KFSs, which may be associated with the suppression of TGF-beta/smad signal pathway. Decitabine transforming growth factor beta 1 Homo sapiens