Title : Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells.

Pub. Date : 2014 Feb

PMID : 24219762






3 Functional Relationships(s)
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1 Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells. Thalidomide delta like canonical Notch ligand 4 Homo sapiens
2 In addition, in vitro effect of thalidomide on Ang2, Notch1 and Dll4 in human umbilical vein endothelial cells (HUVEC) and on HUVEC proliferation was also investigated during normoxic and hypoxic conditions. Thalidomide delta like canonical Notch ligand 4 Homo sapiens
3 CONCLUSION: Ang2, Notch1, Dll4 and Hif-1alpha may play an important role in the pathogenesis of GIVM and may be potential targets of thalidomide in the treatment of the disease. Thalidomide delta like canonical Notch ligand 4 Homo sapiens