Title : Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers.

Pub. Date : 2013 Dec

PMID : 24219283






3 Functional Relationships(s)
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1 Treatment of RCC cell lines with interferon alpha (IFN-alpha) increased thymidine phosphorylase levels and prior treatment of RCC cell lines with IFN-alpha followed by 5-FU or DFUR resulted in enhanced sensitivity of all cell lines to 5-FU and two of three cell lines to DFUR. Fluorouracil interferon alpha 1 Homo sapiens
2 Treatment of RCC cell lines with interferon alpha (IFN-alpha) increased thymidine phosphorylase levels and prior treatment of RCC cell lines with IFN-alpha followed by 5-FU or DFUR resulted in enhanced sensitivity of all cell lines to 5-FU and two of three cell lines to DFUR. Fluorouracil interferon alpha 1 Homo sapiens
3 In addition, our in vitro cytotoxicity results showed that RCC cell lines differed in their response to 5-FU and DFUR and prior treatment with IFN-alpha potentiated cytotoxic response to metabolites of capecitabine. Fluorouracil interferon alpha 1 Homo sapiens