Title : Nicotine effect on inflammatory and growth factor responses in murine cutaneous wound healing.

Pub. Date : 2013 Dec

PMID : 24201082






2 Functional Relationships(s)
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1 Nicotine injection in full-thickness excisional skin wounds minimally affected inflammatory mediators like TNF, IL-6 and IL-12 while it induced a down-regulation in the expression of growth factors like VEGF, PDGF, TGF-beta1 and TGF-beta2, and the anti-inflammatory cytokine IL-10. Nicotine vascular endothelial growth factor A Mus musculus
2 Moreover, nicotine was shown to down-regulate VEGF, PDGF and TGF-beta1 in both bone marrow derived macrophages and RAW 264.7 cells. Nicotine vascular endothelial growth factor A Mus musculus