Pub. Date : 2014 Jan
PMID : 24200896
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To test this we activated heat-sensitive TRPV1 receptors in mice by water that is warmer than body temperature (41 C) or a low dose of resiniferatoxin (RTX). | resiniferatoxin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |
| 2 | To test this we activated heat-sensitive TRPV1 receptors in mice by water that is warmer than body temperature (41 C) or a low dose of resiniferatoxin (RTX). | resiniferatoxin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |
| 3 | Although a desensitizing regimen of RTX (3-5 injections of 0.1 mg/kg s.c.) decreased immobility during swims at 26 C, it did not during swims at 41 C. In contrast, low dose of RTX (0.02 mg/kg s.c.) enhanced immobility, but only during swims at 41 C. Thus, activation of TRPV1 receptors, endogenously or exogenously, enhances immobility and these sites are activated by cold rather than warmth. | resiniferatoxin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |
| 4 | Although a desensitizing regimen of RTX (3-5 injections of 0.1 mg/kg s.c.) decreased immobility during swims at 26 C, it did not during swims at 41 C. In contrast, low dose of RTX (0.02 mg/kg s.c.) enhanced immobility, but only during swims at 41 C. Thus, activation of TRPV1 receptors, endogenously or exogenously, enhances immobility and these sites are activated by cold rather than warmth. | resiniferatoxin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |
| 5 | ), each inhibited the increase in immobility induced by the low dose of RTX, verifying its mediation by TRPV1 sites. | resiniferatoxin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |