Title : USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15.

Pub. Date : 2014

PMID : 24196443






1 Functional Relationships(s)
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1 This study demonstrated that USP3, an apparent DUB for mono-ubiquitinated H2A, is indeed the enzyme for deubiquitinating Ub conjugates of gammaH2AX and H2A from lysine sites, where the ubiquitination is initiated by RNF168. gammah2ax ring finger protein 168 Homo sapiens