Title : Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells.

Pub. Date : 2014 Jan

PMID : 24191259






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1 Furthermore, pretreatment with 25 muM l-buthionine sulfoximine to deplete intracellular glutathione markedly enhanced lapatinib cytotoxicity. Lapatinib latexin Homo sapiens