Pub. Date : 2014 Oct
PMID : 24184699
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CCL2 induction by 1,25(OH)2D3 in dendritic cells from healthy donors and multiple sclerosis patients. | Calcitriol | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | In this study we analyzed the role of 1,25(OH)2D3, the bioactive vitamin D metabolite, in the regulation of CCL2 expression by dendritic cells (DC) obtained from healthy donors and relapsing-remitting MS patients. | Calcitriol | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | We report that 1,25(OH)2D3, as well as 25OHD3, its main blood precursor, induce the secretion of high levels of CCL2. | Calcitriol | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | Moreover, we observed that 1,25(OH)2D3 is able to induce a significant CCL2 secretion in DC obtained from relapsing-remitting MS patients, although CCL2 levels in these latter are lower with respect to healthy controls. | Calcitriol | C-C motif chemokine ligand 2 | Homo sapiens |
| 5 | However, we propose CCL2 as a molecular player contributing to the immunomodulatory activity of 1,25(OH)2D3 on DC, and hypothesize a role for this chemokine in the response of MS patients to vitamin D therapy. | Calcitriol | C-C motif chemokine ligand 2 | Homo sapiens |